Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques *Direct sorting split and pool combinatorial synthesis *Linkers and their applications *Microwave assisted synthesis *Oligosaccharide chemistry *Peptide Synthesis and Screening *Polymer assisted approaches *Small molecule and heterocycle synthesis
This informative text explains the origins of combinatorial chemistry and provides a context for the many diverse library methods. It explains why some techniques are generally applicable while others are for specialists only.
K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry At long last, the mechanism-based and application-oriented handbook of combinatorial chemistry.Since its very beginning, research in this field has...
+ Department of Chemistry and the Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla ... We have recently developed two new combinatorial synthesis strategies employing non - chemical encoding and directed ...
"" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."
While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses.
Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.
Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the
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With contributions by numerous experts
Yu, Z., Yu, X.C., Chu, Y.H. 1998. MALDI-MS determination of cyclic peptidomimetic sequences on single beads directed toward the generation of libraries. Tetra. Lett. 39, 1. chapter five Reaction optimization using spectrophotometric and ...