The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com
The Practice Of Medicinal Chemistry, 3/e
Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process.
(From Clayton T, Chen JL, Ernst M et al. [2007] Curr Med Chem 14:2755–2775. With permission from Bentham Science Publishers.) B: Cook's GABAA receptor pharmacophore (rotated 180° counterclockwise) with a flavone mapped onto the model.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
P. Vogel, Chimia 2001, 55, 359. (a) J.S. Houlton, W.B. Motherwell, B.C. Ross, M.J. Tozer, D.J. Williams, and A.M.Z. Slawin, Tetrahedron 1993, 49, 8087. (b) T.F. Herpin, W.B. Motherwell, and M.J. Tozer, Tetrahedron: Asymmetry 1994, 5, ...
This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions.
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery.
This book introduces the principles and practices of modern medicinal chemistry and covers all aspects of drug discovery from the initial lead to final development. It teaches how to convert...
... by x-ray crystallographic analysis. Tetrahedron 70:2894–2904. (c) Alluri, S. S., and Ganguly, A. K. 2018. Design and synthesis of HIV-1 protease inhibitors. Frontiers in Clinical Drug Research-HIV 4:1–33. 26. Biswas, D., Samp, L., ...