Cancer Immunotherapy: Chapter 29. HyperAcute Vaccines: A Novel Cancer Immunotherapy
- ISBN-10
- 0128059257
- ISBN-13
- 9780128059258
- Series
- Cancer Immunotherapy
- Category
- Medical
- Pages
- 684
- Language
- English
- Published
- 2013-06-04
- Publisher
- Elsevier Inc. Chapters
- Authors
- Gabriela R. Rossi, Nicholas N. Vahanian, W. Jay Ramsey
Description
The hyperacute rejection of a xenotransplant is characterized by a complement-antibody mediated immune response dependent on αGal epitopes. Animal studies confirm that αGal epitopes expressed on allogeneic tumor vaccines elicit a potent T-cell-dependent antitumor immunity. Based on these immunologic reactions, we hypothesized that the hyperacute rejection mechanism could be exploited to alter antigen processing resulting in a novel therapeutic approach to treat human malignancies. Clinical trials data confirm that an immediate hypersensitivity response directed toward a vaccine composed of genetically modified allogeneic tumor cells expressing the xenoantigen αGal (HyperAcute vaccines) constitutes a polyvalent tumor cell vaccine with signs of clinical efficacy, concomitant to eliciting both a humoral IgG response as well as T-cell-mediated antitumor immunity. This conceptually innovative immunotherapy degrades tumoral immune escape and portends a promising genetic engineering tactic for the cost-effective development of a generally applicable human cancer vaccine principle with minimal toxicity. Encouraging results support additional clinical immunotherapy studies using HyperAcute vaccines.
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Other editions
-
- 2013-06-04
- 684 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-04
- 684 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-04
- 684 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-04
- 684 pages
- Ebook
- Elsevier Inc. Chapters
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