Autophagy: Chapter 15. Selenite-Mediated Cellular Stress, Apoptosis, and Autophagy in Colon Cancer Cells
- ISBN-10
- 0128069201
- ISBN-13
- 9780128069202
- Series
- Autophagy
- Category
- Medical
- Pages
- 360
- Language
- English
- Published
- 2013-07-29
- Publisher
- Elsevier Inc. Chapters
- Author
- Emil Rudolf
Description
Colorectal carcinoma (CRC) continues to be a major problem in developed countries, and successful preventive strategies concerning this malignancy are still missing. Sodium selenite has emerged as a potential chemopreventive agent due to a number of special effects which produce colon cancer cells, regardless of their status. Selenite has been able to decrease cell proliferation and induce cytotoxicity by several mechanisms. These include direct inhibition of several molecular targets, signaling pathways (p53-dependent, mTOR, p38, JNK), or subcellular compartments (mitochondria), as well as activation of apoptosis and autophagy. Our data combined with results of studies conducted by other research groups demonstrate a close connection between selenite-induced oxidative stress and apoptosis. In addition, the concurrent existence of autophagy and apoptosis in selenite-treated cells, their mutual relationship, and diverse regulatory patterns upon differing p53 status of cells suggest a multilevel regulation of both processes which warrants future studies.
Get the book
Other editions
-
- 2013-09-03
- 440 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-09-03
- 440 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-07-29
- 360 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-07-29
- 360 pages
- Ebook
- Elsevier Inc. Chapters
Similar books
-
How Institutions are Shaping the Future of Our Children: For Better or for Worse?
By Catherine Dulmus, Karen SowersLammert, M., & Timberlake, E. M. (1986). Termination of foster care for the older adolescent: Issues of emancipation and individuation.
-
Reversibility of Chronic Disease and Hypersensitivity, Volume 5: Treatment Options of Chemical Sensitivity
By William J. Rea, Kalpana D. PatelDou, L., E. Bertrand, C. Cerini, V. Faure, J. Sampol, R. Vanholder, Y. Berland, P. Brunet. ... A. Timberlake, B. Sumpio, R. Pfragner, I. M. Modlin, M. Kidd.
-
Rockwood and Green's Fractures in Adults
By William Ricci, Charles M. Court-Brown, Margaret M. McQueenChendrasekhar A, Moorman DW, Timberlake GA. An evaluation of the effects of ... Chittiboina P, Wylen E, Ogden A, et al. Traumatic spondylolisthesis of the ...
-
Breast Pathology, An Issue of Surgical Pathology Clinics
By Laura C. CollinsHartmann LC, Radisky DC, Frost MH, et al. Understanding the premalignant potential of ... D'Alfonso TM, Wang K, Chiu YL, et al. Pathologic upgrade rates on ...
-
Telepractice in Speech-Language Pathology
By K. Todd HoustonStensland, J., Speedie, S., Ideker, M., House, J., & Thompson, T. (1999). The relative cost of outpatient ... Deal, J. L. (1987). Appraisal and diagnosis of ...
-
Addressing Adversity: Prioritising adversity and trauma-informed care for children and young people in England.
By Marc Bush, Lord Victor Adebowale, Rebecca Adlington1 2 Howard, S. and Johnson, B. (2000) Resilient and Non-resilient Behaviour in ... 4 De Haan, L., Hawley, D. and Deal, J. (2002) 'Operationalizing family ...
-
Culture, Brain, and Analgesia: Understanding and Managing Pain in Diverse Populations
By Mario Incayawar, Knox H. Todd... are not fluent in the language/s of the medical care provider.72 Research ... Anglo-Americans have traditionally placed a great deal of emphasis on the ...
-
Image-Guided Spine Interventions
By John M. MathisThis practical guide thoroughly discusses both well-established and new interventions that are applied to the spine for the purpose of pain relief.
-
New Mynursinglab -- Access Card -- For Maternal-Child Nursing (24-Month Access)
By Pearson Education, Pearson Education, Inc., David P Pearson EducationSeveral versions of Pearson's MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable.
-
Pearson's Medical Assisting (General)
By Pearson Education Staff, Madan Dr Pearson EducationIf a picture paints a thousand words, imagine what video can do? Pearson Medical Assisting Videos help users learn the nuances and the details of many medical assisting procedures.