This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Ramiro Toribio in collaboration with Consulting Editor Dr. Thomas Divers, is devoted to Diseases of Donkeys and Mules. Topics include: ?Endocrine and metabolic disorders of donkeys;?Gastrointestinal disorders of donkeys and mules;?Clinical pathology of donkeys;?Genetics, evolution, physiology in donkeys/mules;?Nutrition and malnutrition;?Donkey and mule welfare;?Dermatological disorders of donkeys/mules;?Anesthesia, analgesia, and sedation in donkeys/mules;?Dental disorders of donkeys;?Clinical evaluation and preventative care of the donkey;?Respiratory disorders of donkeys;?Donkey and mule behavior;?Clinical Pharmacology of donkeys;?Key aspects of donkey and mule reproduction;?and Foot Care and Practical Farriery for the Donkey