Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Toxicologic Pathology in Safety Assessment

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Toxicologic Pathology in Safety Assessment
ISBN-10
0323910521
ISBN-13
9780323910521
Category
Medical
Language
English
Published
2023-02-01
Publisher
Academic Press
Authors
Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon

Description

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety. Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field. New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity. Chapters dealing with product-specific practices address pathology and regulatory issues. Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts. Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts.

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