Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies
ISBN-10
0470022566
ISBN-13
9780470022566
Category
Medical
Pages
238
Language
English
Published
2006-05-01
Publisher
John Wiley & Sons
Authors
Robert Crichton, Roberta Ward

Description

This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

Similar books

  • Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics
    By Michael Aschner, Anthony R. White, Lucio G. Costa

    This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology.

  • Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
    By Robert Crichton

    Chandler, R.J. and Venditti, C.P. (2005) Genetic and genomic systems to study methylmalonic acidemia Mol. Genet. Metab., 86, 34–43. Chen, H., Huang, G., Su, T., et al. (2006) Decreased hephaestin activity in the intestine of ...

  • Oxidative Stress and Neurodegenerative Disorders
    By G. Ali Qureshi, S. Hasan Parvez

    This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress.

  • Medicinal Inorganic Chemistry
    By Jonathan L. Sessler

    This book, a compilation by experts in the field, is designed to provide an introduction to the area of medicinal inorganic chemistry and to summarize current, state-of-the-art developments in the...

  • Neurodegenerative Diseases
    By Celia Dominguez

    - Glutamate and Neurodegenerative Disease.- Modulation of the Kynurenine Pathway for the Potential Treatment of Neurodegenerative Diseases.- Spinal Muscular Atrophy: Current Therapeutic Strategies

  • Biological Inorganic Chemistry: An Introduction
    By Robert R. Crichton

    Curtain, C.C., Ali, F., Volitakis, I., Cherny, R.A., et al. (2001) Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits ...

  • Molecular Mechanisms of Neurodegenerative Diseases
    By Marie-Francoise Chesselet

    Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new ...

  • Imaging in Neurodegenerative Disorders
    By Luca Saba

    This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

  • Neurodegenerative Diseases
    By Uday Kishore

    This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson ...

  • Advances in Mitochondrial Medicine
    By Roberto Scatena, Patrizia Bottoni, Bruno Giardina

    Mitochondria are far more than the “powerhouse” of the cell as they have classically been described.