Multidisciplinary resource for graduate studies and the biotechnology industry
Knowledge of the genetic basis of biological functioning continues to grow at an astronomical rate, as do the challenges and opportunities of applying this information to the production of therapeutic compounds, specialty biochemicals, functional food ingredients, environmentally friendly biocatalysts, and new bioproducts from renewable resources. While genetic engineering of living organisms transforms the science of genomics into treatments for cancer, diabetes, and heart disease, or products for industry and agriculture, the science and technology of bioseparations are the keys to delivering these products in a purified form suitable for use by people.
The methods, theory, and materials that reduce the science of bioseparations to practice, whether in the laboratory or the plant, are the subjects of Bioseparations Engineering. Examples address purification of biomolecules ranging from recombinant proteins to gene therapy products, with footnotes detailing economics of the products. Mechanistic analysis and engineering design methods are given for:
* Isocratic and gradient chromatography
* Sedimentation, centrifugation, and filtration
* Membrane systems
* Precipitation and crystallization
Topics addressed within this framework are: stationary phase selection; separations development; modeling of ion exchange, size exclusion, reversed phase, hydrophobic interaction, and affinity chromatography; the impact of regulatory issues on chromatography process design; organization of separation strategies into logical sequences of purification steps; and bridges between molecular biology, combinatorial methods, and separations science.
A result of teaching and developing the subject matter over ten years, Bioseparations Engineering is an ideal text for graduate students, as well as a timely desk book for process engineers, process scientists, researchers, and research associates in the pharmaceutical, food, and life sciences industries.
J. P. Pearson , K. M. Gray , L. Passador , K. D. Tucker , A. Eberhard , B. H. Iglewski , and E. P. Greenberg , Proc . Natl . Acad . Sci . USA , 1994 , 91 , 197 . 94. J. P. Pearson , L. Passador , B. H. Iglewski , and E. P. Greenberg ...
rubber subjected to the following thermal treatments : cool rapidly to – 40 ° C , hold for 24 hr ; raise rapidly to – 5 ... Bryant 1947. W. M. D. Bryant , “ Polythene Fine Structure , ” J. Polym . Sci . 2 , 547–564 ( 1947 ) . Bunn 1953.
感谢尼尔·斯蒂芬斯为本书设计了漂亮的封面和插图。朱丽娅·珀西瓦尔不仅为本书制作了出色的图表,而且阅读了我的文稿并对开头的几章提出了自己的意见,感谢你超出职责范围的额外贡献。大英图书馆的工作人员都是热心人,尤其是科技类阅览室的。
飞鸟、奈良、平安时代:日本香道初发展兰奢待,日本现存最大的沉香处于隋唐时期的日本也出现了其历史上的第一块沉香。据《日本书记》记载,“推古三年(公元595年,隋文帝开皇十五年)有沈木(指沉香木)漂于淡路岛(日本本州与四国之间,濑户内海中),其大一围, ...
This volume covers the three main transport process of interest to chemical engineers - momentum transfer (fluid flow), heat transfer and mass transfer and the relationships between them.
Chemical Engineering: Solutions to the problems in Chemical engineering, vol. 1
Krieger , Gary R. and Ian Austin . 1995. “ International Legal and Legislative Framework . ” Accident Prevention Manual for ... Miller , Jeffrey G. 1985. “ Marine Protection , Research and Sanctuaries Act . ” Environmental Law Handbook ...
The latest edition of the bestselling Groundwater Chemicals Desk Reference contains double the amount of data found in the original edition. Hundreds of chemicals and chemical compounds are easily located in this latest edition.
P. Allen and D. J. Tildesley , Computer Simulation of Liquids , Clarendon Press , Oxford , 1989 ; D. Frenkel and B. Smit , Understanding Molecular Simulations : From Algorithms to Applications , Academic Press , San Diego , 1996 .
''Bottom line: For a holistic view of chemical engineering design, this book provides as much, if not more, than any other book available on the topic.' Extract from Chemical Engineering...