Genetic and Serological Markers Associated with Pouchitis and a Crohn's Disease-like Phenotype After Pelvic Pouch Surgery for Ulcerative Colitis
- ISBN-10
- 0494596880
- ISBN-13
- 9780494596883
- Pages
- 354
- Language
- English
- Published
- 2009
- Author
- Diane Sharon Verbeeten
Description
Objective. Study the clinical, genetic and serological factors associated with new onset ileal inflammation in ulcerative colitis (UC) patients who have undergone ileal pouch-anal anastomosis (IPAA).Methods. Retrospective assessment of UC patients registered in the MSH surgical database, questionnaire, chart review and serological and genetic analysis of blood sample.Results. There was a positive association between gASCA antibodies, anti-L, smoking status and axial arthritis/ankylosing spondylits with a Crohn's Disease (CD)-like phenotype post-op in UC/IPAA patients. Associations between alleles of selected genes including ECM1, PTPN2, and CD14 and post-operative phenotype were identified.Conclusions. gASCA is typically associated with CD rather than UC which raises the possibility that gASCA positivity may delineate a subset of UC patients at risk for developing a CD-like phenotype after IPAA. The identification of genotype/phenotype associations in UC/IPAA will help to find those at risk for poor post-operative outcome. Prospective studies are needed to confirm these findings.
