Epidermal Stem Cells are Multipotent and Resist Cellular Aging

ISBN-10: 0549060332
ISBN-13: 9780549060338
Category: Stem cells
Pages: 322
Language: English
Published: 2007
Author: Matthew Michael Stern

Description

In addition to their ability to generate the epidermal keratinocyte lineage, epidermal stem cells have been shown to be multipotent, or possess the ability to produce cells within a variety of non-epidermal cell lineages. To address some weaknesses in such previous studies and further demonstrate the specificity of somatic stem cell multipotency, I set out to determine if epidermal stem cells could be guided to produce a designated cell type within an alternate cell lineage in culture. I targeted the B lymphocyte lineage of the hematopoietic system. Using a culture system reliant upon bone marrow stromal cells and cytokine-enriched medium, I was able to drive the development of B lymphocyte precursors from epidermal stem cells. This led me to conclude that the multipotency of epidermal stem cells is a real and potentially exploitable property that could prove useful in future applications of stem cell-based therapeutics.

Get the book

Similar books

Stem Cells: A Very Short Introduction
By Jonathan Michael Wyndham Slack
Developmental biologist Jonathan Slack explains the biology behind stem cells - what they are, what scientists do with them, what stem cell therapies are available today, and what can be expected to happen in the future.
What is the Controversy with Stem Cell Research?
By Isabel Thomas
This addition to the Sci-hi series explains what stem cells are, where they come from, and how doctors and scientists hope to use them.
Stem Cells: From Biological Principles to Regenerative Medicine
By Cristina Lo Celso, Kristy Red-Horse, Fiona M. Watt
This book examines recent progress in our understanding of the biology of these cells, how they are regulated, and opportunities for using them in disease therapies"--
Encyclopedia of Stem Cell Research

"Provides an understanding of the basic concepts in stem cell biology and addresses the politics, ethics, and challenges currently facing the field"--From publisher description.
Stem Cells: Biology and Application
By Mary Clarke, Jonathan Frampton
Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.
Cloning, Genetics And Stem Cell Technology: Developments And Applications
By Dr. Ruchi Dhawan
This is the first handbook on the whole field of stem cell covering (1) molecular and cellular fundamentals, (2) clinical applications and (3) CMP processing.
iPS細胞の産業的応用技術

そこで本研究では,ヒト iPS 細胞から造血幹細胞を分化誘導する系を確立し,さらに,生体内の環境を再現した, Biomimetic なニッチ(人工幹細胞ニッチ)を構築することで,造血幹細胞の培養条件を最適化し, iPS 由来造血幹細胞の挙動を制御する技術基盤の確立を ...
Stem Cell Research: Medical Applications and Ethical Controversy
By Joseph Panno
Examines stem cells from the scientific and social viewpoints, including what they are, their laboratory study, their use in medicine, the ethical issues involved, and the legal issues in American and Europe.