Teratogenic exposures during embryonic or foetal life can produce permanent abnormalities of structure or function. Although the number of individuals affected is relatively small - perhaps accounting for about one-tenth of all birth defects - teratogenic exposures are nevertheless important because they are potentially preventable. In this volume J.M. Friedman, MD, PhD, and Janine E. Polifka, PhD, present an updated version of their catalogue for clinicians. With more than 1100 agent summaries, this new edition expands the clinically orientated information now available on the potential teratogenic effects of drugs and other agents on the developing foetus or embryo. The catalogue offers a rating system by which an internationally recognized panel of teratologists assesses the risk associated with usual exposures to each agent. Also rated are the quality and quantity of data upon which the panel's assessment is based. Each entry includes a concise narrative summary that reviews the available information as well as a list of key references.
However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment.
Donahue et al ( 1999 ) found that a ligand of the peripheral - type benzodiazepine rectptor , PK11195 , protected treated mice . Charlap et al . ( 2003 ) in a study of the pathogenesis of this drug showed that the mitochondrial ...
Abstract: This book addresses the use of drug groups for various clinical indications during pregnancy. In general, non-pharmacologic remedies are recommended if these will suffice before drug therapy is instituted....
At some point, the well-being of a second person, a fetus, might also have to be taken into account. Epilepsy in Women provides a detailed guide to this challenge.
This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims.
Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and ...
"A pregnant woman should not take any drug unless it is necessary for her own health or that of her fetus," note J. M. Friedman and Janine Polifka. "Counseling a...
This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, ...
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes.
A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.