Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry
- ISBN-10
- 0841233985
- ISBN-13
- 9780841233980
- Category
- Drug development
- Pages
- 320
- Language
- English
- Published
- 2019-09-17
- Authors
- Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan
Description
The chapters in this book are written to accentuate the interdependency and synergy between drug discovery and process development disciplines to advance a new chemical entity into clinical trials and eventually to the market. Due to the success of our previous books (Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development, Volumes 1 and 2), the editors sought to further arm experienced modern synthetic organic chemists, and budding researchers perhaps still in universities with real world examples from the pharmaceutical industry. In addition, the chapters contain citations of a large number of valuable selected references to the primary literature. The book highlights the tireless efforts of Discovery and Process Chemists, and their roles in the advancement of drug discovery and development. The editors were motivated to create this book by our appreciation of the value of chemical research by both Discovery and Process Chemists in producing new pharmaceutical entities. Their combined efforts make it possible to introduce novel and effective drugs into the market to treat hundreds of millions of patients and alleviate their suffering, improve their quality of life and possibly save their lives from diseases and disorders. The chapters presented in this book are written by a selected group of outstanding, highly accomplished Medicinal and Process Chemists with noted experiences and diverse backgrounds representing some of the top pharmaceutical companies. The chapters highlight examples of emerging concepts, new developments and challenges arising in the discovery of new drug candidates and the development of new practical synthetic chemistry processes to produce these drug candidates on large scale. The story leading up to the discovery of each drug or drug candidate is presented by the Discovery Chemist(s), and then the Process Chemist(s) describe the development of the same drug to give the reader a complete story of drug discovery and development. The reader will experience a rare and unique opportunity to obtain the complete perspectives of Discovery and Process Chemistry in a single book. While most of these topics have appeared in the primary literature where space is critical and brevity valued, the book permits the editors and contributors to tell the complete tales as stories, from start to finish or to the current state of the drug development.
Get the book
Similar books
-
Private Profits versus Public Policy: The Pharmaceutical Industry and the Canadian State
By Joel LexchinAvailable from: http://www.cihr-irsc. gc.ca/e/34742.html. Bernstein A. Toward effective Canadian public-private partnerships in health research. CMAJ. ... Tyers M, Brown E, Andrews DW, et al. Problems with co-funding in Canada. Science.
-
Systems Thinking in Medicine and New Drug Discovery
By Robert E. SmithThis book will appeal to specialists, who will find recommendations on safer materials for 3D bioprinting and ways to analyze dietary supplements for toxic contaminants, and physicians, pharmacists and non-professionals, who will learn the ...
-
Synthetic Methods in Drug Discovery: Volume 1
By David C. Blakemore, Paul M. Doyle, Yvette M. FobianWhat are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules.
-
The Pathway to Operational Excellence in the Pharmaceutical Industry: Overcoming the Internal Inertia
By Thomas FriedliDas beeinträchtigte Innovationen im Produkt- und Substanzbereich. Veränderungen werden an Geschwindigkeit und Umfang zunehmen. Hier setzt die Operational Excellence ein.
-
Design and Delivery of SiRNA Therapeutics
By Henrik J. Ditzel, Martina Tuttolomondo, Sakari KauppinenThis volume details protocols on rationale design of therapeutic siRNA molecules and its encapsulation with smart vehicles to overcome the barriers to an effective administration in vivo.
-
Drug Target Selection and Validation
By Marcus T. Scotti, Carolina L. BelleraConcepts and case studies in chemical biology. John Wiley & Sons, Inc.; 2014. Pai MY, et al. Drug affinity responsive target stability (DARTS) for small-molecule target identification. Methods Mol Biol. 2015;1263:287–98. Rock FL, et al.
-
Burger's Medicinal Chemistry, Drug Discovery and Development
By Donald J. AbrahamBringing in a new and expert editorial board, this new edition updates existing chapters and adds 35 new ones, with topics including: opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, ...
-
Pharmacological Research on Traditional Herbal Medicines
By WantanabeIntroducing many pharmacological advances made, the work also describes the modern theories and scientific methodologies applied to today's studies on herbal medicines and new drug development.
-
Pharmaceutical Innovation: Revolutionizing Human Health
By Basil Achilladelis, Ralph Landau, Alexander ScriabineDocuments how science has provided an astonishing array of medicines for coping with human ailments. This volume addresses industry leaders, economic influences, and the development of individual products.
-
Capitalizing a Cure: How Finance Controls the Price and Value of Medicines
By Victor Roy... drug development. Soothing the “ups and downs” of finance that Gilead's founder, Riordan, had warned his employees about many years ago required a balm of its own sort, one not discovered in its laboratories but driven by Wall Street ...