This Resource Guide is intended to provide clinicians serving adult populations in general medical settings with the screening tools and procedures necessary to conduct screening, brief intervention, and/or treatment referral for patients who may have or be at risk of developing a substance use disorder. Screening and brief intervention provides an opportunity for clinicians to intervene early and potentially enhance medical care by increasing awareness of the likely impact of substance use on a patient¿s overall health. Includes: Recommendations to Address Patient Resistance; Sample Progress Notes; Change Plan Worksheet; Biological Specimen Testing; and Additional Resources. Illustrations.