Cigarette smoking and exposure to secondhand smoke kill an estimated 443,000 people in the U.S. each year. For every smoker who dies from a smoking-attributable disease, another 20 live with a serious smoking-related disease. Smoking costs the U.S. $96 billion in medical costs and $97 billion in lost productivity each year. This strategic action plan proposes a comprehensive approach designed to mobilize the Dept. of Health and Human Service's (HHS's) expertise and resources in support of proven, pragmatic, achievable interventions that can be aggressively implemented not only at the federal level, but also within states and communities. The activities described are meant to serve as a guideline for future development. Implementing the strategic actions in this plan can enable the U.S. to meet the Healthy People objective of reducing the adult smoking rate to 12%. Together, the recommended actions offer an historic opportunity to accelerate our efforts to end the tobacco problem. Figures. This is a print on demand report.