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Richard B. Silverman, Mark W. Holladay. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. ... Int. Immunopharmacol. 2010, 10, 784–790. Kline, P. C.; Schramm, V. L. Pre-steady-state transition-state analysis of the hydrolytic ...
... C., Dubin, N., Ferran, V., Stecy, P., Zeleniuch-Jaquotte, A., Wemz, J., Feit, F., Slater, W., Blum, R., and Mugia, F. 1988. ... Murugesan, N., Xu, C., Ehrenfeld, G. M., Sugiyama, H., Kilkuskie, R. E., Rodriguez, L. 0., Chang, L.-H., ...
( b ) Tisdale , M .; Kemp , S. D .; Parry , N. R .; Larder , B. A. Proc . Natl . ... Sucheck , S. J .; Wong , A. L .; Koeller , K. M .; Boehr , D. D .; Draker , K. - a .; Sears , P .; Wright , G. D .; Wong , C.-H. J. Am . Chem . Soc .
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Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems.
The Organic Chemistry of Drug Design and Drug Action
Organic Chemistry of Drug Design
An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed.
Curtis , N.A.C. , Brown , C. , Boxall , M. and Boulton , M.G. , 1979a , Antimicrob . Ag . Chemother . , 15 , 332-6 . Curtis , N.A.C. , Orr , D. , Ross , G.W. and Boulton , M.G. , 1979b , Antimicrob . Ag . Chemother . , 16 , 533-9 .
Over the recent years, medicinal chemistry has become responsible for explaining interactions of chemical molecules processes such that many scientists in the life sciences from agronomy to medicine are engaged...