Intestinal Immune System
- ISBN-10
- 1615041443
- ISBN-13
- 9781615041442
- Category
- Medical
- Pages
- 110
- Language
- English
- Published
- 2011
- Publisher
- Morgan & Claypool Publishers
- Authors
- Soichiro Miura, Ryota Hokari, Shunsuke Komoto
Description
The intestinal mucosa thus shows a unique morphological structure with many immune cells being present under physiological conditions. This condition is known as "controlled inflammation." These abundant immune cells also have characteristic functions: they are "negatively regulated" and have been educated not to overreact unnecessarily to the intestinal luminal milieu. Main players that control inflammation of the intestinal mucosa include regulatory cytokines and regulatory T cells which induce oral tolerance to intestinal bacteria and food antigens, and the secretory IgA system. The maintenance of unique immunological activity in the intestine is also related to an organized, orchestrated lymphocyte migratory mechanism called the "common mucosal immune system." --
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