Combining Human Genetics and Causal Inference to Understand Human Disease and Development
- ISBN-10
- 1621823814
- ISBN-13
- 9781621823810
- Category
- Medical
- Pages
- 225
- Language
- English
- Published
- 2021
- Author
- George Davey Smith
Description
Mendelian randomization and related techniques allow researchers to use knowledge about genetic factors that contribute to a disease to predict whether other risk factors, such as environmental exposure, play a part. This volume examines how these approaches allow researchers to make causal inferences about modifiable exposures and how this can benefit public health. Topics covered in this essential volume include: - The Meaning of "Cause" in Genetics - Twins and Causal Inference: Leveraging Nature's Experiment - Mendelian Randomization: Concepts and Scope - Integrating Family-Based and Mendelian Randomization Designs - Computational Tools for Causal Inference in Genetics - Using Mendelian Randomization to Improve the Design of Randomized Trials
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