Two hundred years after the Siren Virus killed off what was thought to be the last of the female population, Leah Valley is raised by her father and hidden from the male world under the alias "Lee". She and her father seek to find Eden, a safe haven for the surviving women, where her sister and mother live under the unjust rule of the corrupt dictator, Velma. While trying to locate them, Leah and her father are threatened by the CDC who plot to destroy all evidence of the existence of women. When the most dire of circumstances fall upon her, Leah is forced to bring Rider, her lifelong best friend, into her world of secrecy and danger. They both soon learn that the world is not a safe place for a lady.