The purpose of the American Academy of Ambulatory Care Nursing (AAACN) Academic-Practice Guideline(s) is to strengthen nursing practice and lead change in the delivery of care in diverse health care settings by fostering a sustainable, replicable partnership between academic and practice settings. The guidelines will help elevate the professional role of the nurse and ensure positive patient outcomes in multiple care settings.These guidelines were developed through a thoughtful and deliberate process of collecting information and feedback, incorporating current best practices, and expert suggestions. The guidelines provide a clear, useful, and evidence-based guide for effective Academic-Practice Partnerships.