Anti-social behaviors and social deficits induced mental disorders are critical problems in our society today. Social behaviors and interactions are shaped by experience, hereditary components (genes, hormones and neuropeptides) and environmental factors (photoperiods and metabolic signals). In addition to the classical gonadotropin-releasing hormone, RFamide peptides, kisspeptin and gonadotropin-inhibiting hormone are emerging as important regulators of the reproductive axis. These neuropeptides are evolutionarily conserved and are regulated by environmental factors. In this Research Topic, we advocate more recent advances in reproductive neuropeptides and sex steroids in the domains of social behavior including sexual and parental behavior, aggression, stress and anxiety. Using multiple species model, we also review how genes and the neuroendocrine system interact at the cell and organismic levels to contribute to social behavior in particular the epigenetic genomic changes caused by early life environment. We provide comprehensive insights of distinct neural networks and how cellular and molecular events in the brain regulate social behavior from a comparative perspective.
Neurological and psychiatric disorders can occur in endocrine diseases either in the setting of the clinical manifestations of the same (i.e., hyper- or hyposecretion of hormones or peptides from the endocrine glands) or as events secondary ...
Br. J. Psychiatry 128, 379–383. doi: 10.1192/bjp.128.4.379 Oates, M. (2003). Suicide: the leading cause of maternal death. Br. J. Psychiatry 183, 279–281. doi:10.1192/bjp.183.4.279 O'Hara, M. W., Stuart, S., Gorman, L. L., and Wenzel, ...
This book has been written by widely acknowledged experts, with each chapter providing unique information on emerging aspects of T1D.
About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control.
The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands.
Neuroendocrinology is the discipline that investigates the interplay between the nervous and endocrine systems i.e. the control of endocrine glands by the central and peripheral nervous systems, the action of hormones on nerve cells and the ...