Outlining the complex interaction between the two phenomena Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty. This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
Kozloff M, Sugrue M, Purdie D, et al. Safety and effectiveness of bevacizumab and chemotherapy in elderly patients with metastatic colorectal cancer: Results from the BRiTE observational cohort study. J Clin Oncol 2008 (Abstract 4026).
Background Cancer is a variety of malignancies generally associated with aging.
It is difficult to separate the effects of disease on organs and tissues from those expected of aging. This is particularly true for vascular and degenerative processes, for which there are no clear boundaries between aging and disease.
This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s.
Biological Aspects of Cancer and Aging: Studies in Pure Line Mice
This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy.
Aging and Cancer
This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known.
This book will also provide a scaffold to organize rapidly developing advances in geriatric assessment. This is particularly relevant for oncologists since the majority of patients with cancer are 65 and older.
Published in 2004: This new edition of Comprehensive Geriatric Oncology still offers an exhaustive review of the biology of cancer and aging, of the epidemiologic trends in the country and in the world, and of the clinical trials that ...