Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
This book comprehensively discusses the latest research in the area of metabolic engineering.
The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area.
In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises.
Steen EJ, Chan R, Prasad N. Myers S, Petzold CJ, Redding A, Ouellet M, Keasling.JD. (2008) Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microb Cell Fact 7, 36. Steen EJ, KangY, Bokinsky G, Hu Z, ...
Metabolic engineering: new developments and applications
This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development.
Escholarship.org/uc/item/54p5k63q O'Connor SE (2015) Engineering of secondary metabolism. ... Mol Plant 3:2–20 Wink M (2010) Annual plant reviews volume 39: function and biotechnology of plant secondary metabolites, 2nd edn.
... redox cofactor-dependent intracellular enzyme catalysis is expected to interfere with the energy metabolism of the microbial host, since the same cofactors are involved in both redox biocatalysis and energy metabolism.
Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology.
Written by a seasoned computational biologist with many years of experience in genomics, bioinformatics, and systems biology, this book will appeal to anyone interested in metabolic systems analysis and metabolic pathway engineering.