Photopolymerizable Porous Polyorganophosphazenes: Degradable Matrices for Tissue Engineering
- ISBN-10
- 365809320X
- ISBN-13
- 9783658093204
- Category
- Technology & Engineering
- Pages
- 75
- Language
- English
- Published
- 2015-03-11
- Publisher
- Springer
- Author
- Tamara Bernadette Aigner
Description
Tamara Bernadette Aigner designed a set of biocompatible and biodegradable poly(organophosphazenes). In order to tailor their biological and chemical properties, she further modified these macromolecules by adding functional moieties via thiol-ene chemistry. The author used the same photochemistry for crosslinking to obtain a mechanically stable network. She further altered the degradation rate of the matrix as well as the mechanical properties by adding blending agents and created a porous matrix, which is necessary for cell invasion and communication, by a newly developed photocrosslinking particulate-leaching method. Thus, a modular hybrid system was established which is able to adapt to different microenvironments based upon tissue type.
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