Strategies and Tactics in Organic Synthesis: Chapter 5. Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2
- ISBN-10
- 0128056088
- ISBN-13
- 9780128056080
- Series
- Strategies and Tactics in Organic Synthesis
- Category
- Science
- Pages
- 344
- Language
- English
- Published
- 2013-07-29
- Publisher
- Elsevier Inc. Chapters
- Authors
- Masayuki Inoue, Daisuke Urabe
Description
In this chapter, we described the asymmetric total synthesis of merrilactone A and resolvin E2 based on the symmetry-driven strategy. The enantio- and diastereoselective transannular aldol reaction of the meso eight-membered diketone led to the efficient total syntheses of both enantiomers of merrilactone A, and the convergent assembly of the pseudo-enantiomeric fragments, prepared through the enantioselective solvolysis of the meso intermediate, resulted in total synthesis of resolvin E2. These syntheses demonstrate the power and generality of the symmetry-driven strategy for construction of both multicyclic and linear natural products.
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Other editions
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- 2013-07-29
- 344 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-07-29
- 344 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-07-29
- 344 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-07-29
- 344 pages
- Ebook
- Elsevier Inc. Chapters
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