Cancer Immunotherapy: Chapter 24. Immune Stimulatory Features of Classical Chemotherapy

Cancer Immunotherapy: Chapter 24. Immune Stimulatory Features of Classical Chemotherapy
ISBN-10
0128059206
ISBN-13
9780128059203
Series
Cancer Immunotherapy
Category
Medical
Pages
684
Language
English
Published
2013-06-04
Publisher
Elsevier Inc. Chapters
Authors
W. Joost Lesterhuis, Anna K. Nowak, Richard A. Lake

Description

Studies over the past few years have caused a gestalt in thinking about chemotherapy and tumor immunity. Rather than regarding chemotherapy as an immunosuppressive inevitability, it is now recognized that chemotherapeutics can direct and amplify an immune response against cancer. In this chapter, we will review this field with emphasis on the mechanisms behind the immunopotentiating features of classic cytotoxic chemotherapeutics. We will discuss the most recent clinical translations in this field and review the current gaps in our knowledge. In addition we will outline the difficulties that lie ahead in optimally exploiting the immunopotentiating action of classical chemotherapeutics, and describe the way we think this field can move forward.

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