Cancer Immunotherapy: Chapter 25. Immunotherapy and Cancer Therapeutics: A Rich Partnership

Cancer Immunotherapy: Chapter 25. Immunotherapy and Cancer Therapeutics: A Rich Partnership
ISBN-10
0128059214
ISBN-13
9780128059210
Series
Cancer Immunotherapy
Category
Medical
Pages
684
Language
English
Published
2013-06-04
Publisher
Elsevier Inc. Chapters
Authors
Gang Chen, Elizabeth M. Jaffee, Leisha A. Emens

Description

Cancer is managed by surgery, radiation therapy, and systemic drug therapies. Drug therapies include endocrine manipulation, single- or multi-agent chemotherapy, and monoclonal antibody therapy. Targeted small molecules that specifically capitalize on vulnerabilities that map to signaling pathways indispensible for tumor growth and progression are now also a part of the standard of cancer care. More recently, rapidly accumulating data illustrates a critical role for the immune system in the response to chemotherapy, radiation (the abscopal effect), and novel targeted cancer therapies. Integrating immune-based therapies strategically with established and novel cancer therapeutics should generate a robust antitumor effect that takes advantage of the strengths of their individual modes of action and also leverages potential immunologic synergies.

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