Introduction to Biological and Small Molecule Drug Research and Development: Chapter 2. Protein structure and function

Introduction to Biological and Small Molecule Drug Research and Development: Chapter 2. Protein structure and function
ISBN-10
0128061928
ISBN-13
9780128061923
Series
Introduction to Biological and Small Molecule Drug Research and Development
Category
Science
Pages
472
Language
English
Published
2013-05-07
Publisher
Elsevier Inc. Chapters
Author
Jennifer Ann Littlechild

Description

This chapter covers the general features of protein structure and recent advances in structural bioinformatics. The importance of the three-dimensional structure of the protein target in order to understand its mechanism of action as an aid for drug design is illustrated by specific examples of enzyme inhibition, receptor interactions and drugs binding to structural proteins. The impact of proteomics and bioinformatics is stressed, while protein interactions with other proteins and different biological macromolecules are discussed.

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