The constant increase in the number of obese and diabetic patients, which has become a concern of public health, is the consequence of dysregulations in energy homeostasis. Communications between the brain and peripheral tissues play a critical role in this regulation. Studying the brain-periphery axis has become a critical field of research. This chapter lists a panel of concepts, approaches, tools and techniques scientists possess to study the brain-periphery axis in the regulation of energy homeostasis. We focused on techniques used in vivo to stimulate the brain such as the stereotaxy, electrical stimulation, vascular surgery and optogenetic. We described tools and approaches used to study in vivo and in vitro response of neural cells to metabolic stimuli such as electrophysiology, cellular imaging, microdialysis and c-fos mapping. Finally, approaches used to study peripheral behavioral and metabolic responses such as food intake and body weight monitoring and glucose clamps are presented.
The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ...
The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ...
Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy ...
Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier.
Genetically modified animals were created about 30 years ago, and are considered good models of human diseases.
This text provides valuable information in selecting and using suitable animal species for research so that the experimental data can be meaningful and relevant to human disease. It will be...
Thomson JA, ItskovitzEldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147. Chambers I, Smith A. Selfrenewal of teratocarcinoma and embryonic stem cells. Oncogene.
Reward behavior represents a subset of conditioning procedures that have been developed by psychologists to study learning in animals.
Mouse models in skeletal physiology and osteoporosis: Experiences and data on 14,839 cases from the Hamburg Mouse Archives. Journal of Bone and Mineral ... Sourcebook of Models for Biomedical Research. Totowa, NJ: Humana Press; ...
Animal Models for the Study of Multiple Sclerosis Robert H. Miller, Sharyl Fyffe-Maricich, Andrew V. Caprariello. 51. 52. 53. 54. 55. ... Mix E, MeyerRienecker H, Hartung HP, Zettl UK. ... Kaye JF, Kerlero de Rosbo N, Mendel I, et al.