Epigenetics, Nuclear Organization and Gene Function: Implications of Epigenetic Regulation and Genetic Architecture for Human Development and Health

Epigenetics, Nuclear Organization and Gene Function: Implications of Epigenetic Regulation and Genetic Architecture for Human Development and Health
ISBN-10
0198831218
ISBN-13
9780198831211
Category
Science
Pages
304
Language
English
Published
2019-01-15
Publisher
Oxford University Press, USA
Author
John C. Lucchesi

Description

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

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