The Unsettlement of America explores the career and legacy of Don Luis de Velasco, an early modern indigenous translator of the sixteenth-century Atlantic world who traveled far and wide and experienced nearly a decade of Western civilization before acting decisively against European settlement. The book attends specifically to the interpretive and knowledge-producing roles played by Don Luis as a translator acting not only in Native-European contact zones but in a complex arena of inter-indigenous transmission of information about the hemisphere.