Solid-Phase Synthesis and Combinatorial Technologies
- ISBN-10
- 0471460737
- ISBN-13
- 9780471460732
- Category
- Science
- Pages
- 656
- Language
- English
- Published
- 2003-05-28
- Publisher
- John Wiley & Sons
- Author
- Pierfausto Seneci
Description
A unique, integrated look at solid-phase synthesis and advancesin combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorialtechnologies, a field where chemistry disciplines intersect withautomation, statistics, and information science, as well as certainbiological disciplines. Reflecting these multidisciplinary trends,this new work provides a comprehensive overview of the mostimportant aspects of solid-phase synthesis (SPS), combinatorialchemistry, and related combinatorial technologies. It clearlydemonstrates how SPS and combinatorial chemistry have extendedtheir application from the pharmaceutical arena to new areas,including biotechnology, material sciences, catalysis, andagrochemical industries, and explores in detail strategies forplanning, designing, preparing, and testing of combinatoriallibraries in various disciplines. Designed to meet the needs ofboth experienced combinatorial chemists and newcomers to the field,Solid-Phase Synthesis and CombinatorialTechnologies: Surveys the most recent developments in SPS and combinatorialchemistry Explains the entire process, from determining the need for alibrary to the details necessary for synthesis of the library Discusses choice of format, size, and the rationale behind thedesign of each synthetic step Surveys the analytical techniques and the purification methodsused to characterize and purify combinatorial libraries Employs a large number of examples to illustrate importantconcepts Includes problems geared toward applying acquired knowledge anddesigning the steps to SPS/library synthesis Describes the quality control and activity screening ofcombinatorial libraries for various applications Features a detailed bibliography of more than 1,700 relevantsources
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