Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field. Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. From the reviews of the First Edition: "It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION "Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS
NEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * ...
This book aims to be their practical handbook - a complete guide to the drug discovery process.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
Emphasizing applications of chemistry while reinforcing theory -- especially in the areas of organic and physical chemistry -- this new text prepares students for career success in the pharmaceutical, medical, and biotech industries.
These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges.
Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process.
With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical ...
For many years, we stayed confident that solid‐phase combinatorial chemistry was one of them, and we believe that today this is more the case ... Combinatorial Strategies in Biology and Chemistry, John Wiley & Sons, ltd., West Sussex.
Another piece of the puzzle concerning the role of GR in RA is the discovery of a natural existing splice variant of GR, the GR. This protein represents a truncated version of GR (GR), that can translocate to the nucleus and bind to ...
The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices.