Depolarization of the rod bipolar cells elicited glutamate release and activated EAAT5 transporters. This chloride current, was inhibitory and novel. As with some photoreceptors (see above), activation of EAAT5 causes negative feedback ...
The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs ...
This book is a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It provides an overview of insights generated in the past five years.
General Description of the Series: Neurotransmitter Transporters focuses on biochemical, electrophysiological, pharmacological, molecular, and cell biological approaches used to study neurotransmitter transport systems.
It will also be of interest to physicians who are carrying out imaging and postmortem studies of neurotransmitter transporters in the human brain.
Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles.