Introduction to Biological and Small Molecule Drug Research and Development: Chapter 8. Discovery and development of the anticancer agent gefitinib,...
- ISBN-10
- 0128061987
- ISBN-13
- 9780128061985
- Series
- Introduction to Biological and Small Molecule Drug Research and Development
- Category
- Science
- Pages
- 472
- Language
- English
- Published
- 2013-05-07
- Publisher
- Elsevier Inc. Chapters
- Authors
- Andy Barker, David Anrews
Description
The epidermal growth factor receptor (EGFR) tyrosine kinase is a target for cancer chemotherapy. This chapter describes the discovery of small-molecule inhibitors of the kinase, their characterization and the medicinal chemistry programme that resulted in the identification of gefitinib. The development and studies undertaken to progress the drug in the clinic are presented together with a brief summary of other inhibitors of the EGFR kinase and their properties.
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Other editions
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- 2013-05-07
- 472 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-05-07
- 472 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-05-07
- 472 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-05-07
- 472 pages
- Ebook
- Elsevier Inc. Chapters
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