For several decades the incidence and prevalence of chronic inflammatory diseases have been increasing, particularly in westernized countries. These diseases include allergic conditions (asthma, eczema) as well as autoimmune diseases. It is now well established that the development of clinical phenotypes is the result of an intimate interaction between genetic predisposition and environmental exposures. The adaptive immune system plays an important role in orchestrating the inflammatory response. In this regard, T-helper cell differentiation into Th1, Th2, Th17, Treg and other T-cell subsets plays an important role. Recent data further indicate that there is a high degree of flexibility and plasticity among these effector cells. T-helper cell differentiation is tightly controlled by epigenetic mechanisms. These include DNA methylation, histone acetylation and the role of microRNA. Epigenetic regulation represents an important mode of action for environmental factors – including nutritional agents, stress and microbial compounds – to regulate gene expression resulting in disease development.
Lammert, M., & Timberlake, E. M. (1986). Termination of foster care for the older adolescent: Issues of emancipation and individuation.
Dou, L., E. Bertrand, C. Cerini, V. Faure, J. Sampol, R. Vanholder, Y. Berland, P. Brunet. ... A. Timberlake, B. Sumpio, R. Pfragner, I. M. Modlin, M. Kidd.
Chendrasekhar A, Moorman DW, Timberlake GA. An evaluation of the effects of ... Chittiboina P, Wylen E, Ogden A, et al. Traumatic spondylolisthesis of the ...
Hartmann LC, Radisky DC, Frost MH, et al. Understanding the premalignant potential of ... D'Alfonso TM, Wang K, Chiu YL, et al. Pathologic upgrade rates on ...
Stensland, J., Speedie, S., Ideker, M., House, J., & Thompson, T. (1999). The relative cost of outpatient ... Deal, J. L. (1987). Appraisal and diagnosis of ...
1 2 Howard, S. and Johnson, B. (2000) Resilient and Non-resilient Behaviour in ... 4 De Haan, L., Hawley, D. and Deal, J. (2002) 'Operationalizing family ...
... are not fluent in the language/s of the medical care provider.72 Research ... Anglo-Americans have traditionally placed a great deal of emphasis on the ...
This practical guide thoroughly discusses both well-established and new interventions that are applied to the spine for the purpose of pain relief.
Several versions of Pearson's MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable.
If a picture paints a thousand words, imagine what video can do? Pearson Medical Assisting Videos help users learn the nuances and the details of many medical assisting procedures.