Diet, immunity and inflammation: 15. Flavonoids and immune function

Diet, immunity and inflammation: 15. Flavonoids and immune function
ISBN-10
0128087072
ISBN-13
9780128087077
Series
Diet, immunity and inflammation
Category
Medical
Pages
760
Language
English
Published
2013-09-30
Publisher
Elsevier Inc. Chapters
Authors
M. Serafini, F. Ioannone, C. Miglio

Description

It has been suggested that flavonoids, secondary metabolites widely present in the vegetable kingdom, are involved in the role played by plant foods in disease prevention. The immune-modulating action of flavonoids in vitro suggests a specific role in modulating cytokines and transcription factors such as nuclear factor kappa B (NFκB). However, the majority of studies have been conducted with non-physiological concentrations of flavonoids and without considering the nature of the metabolites found in the bloodstream. In humans, the number of studies is limited and the results are contrasting, leaving open the debate about the role of flavonoids as modulators of immune response.

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