Diet, immunity and inflammation: 17. Modulation of inflammatory and immune responses by short-chain fatty acids
- ISBN-10
- 0128087099
- ISBN-13
- 9780128087091
- Series
- Diet, immunity and inflammation
- Category
- Medical
- Pages
- 760
- Language
- English
- Published
- 2013-09-30
- Publisher
- Elsevier Inc. Chapters
- Authors
- M.A.R. Vinolo, H.G. Rodrigues, R.T. Nachbar
Description
Short-chain fatty acids (SCFAs) are the main metabolic products of anaerobic bacterial fermentation in the intestine. In addition to their important role as fuel for intestinal epithelial cells, SCFAs modulate different processes in the gastrointestinal (GI) tract and in other tissues such as adipose and immune tissues. In this chapter, we first present a brief description of basic aspects of SCFA physiology, such as production, absorption and metabolism. The main mechanisms by which SCFAs act on cells and the effects of these fatty acids in isolated leukocytes are then discussed. We also highlight the results obtained by studies performed in vivo using SCFAs in the treatment of inflammatory pathologies. A brief discussion about the perspectives in this research field is presented at the end of the chapter.
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Other editions
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- 2013-09-30
- 760 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-09-30
- 760 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-09-30
- 760 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-09-30
- 760 pages
- Ebook
- Elsevier Inc. Chapters
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